Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism
2021-06-23
Sandra Nitsch, Lara Zorro Shahidian, Robert Schneider
In eukaryotic cells, DNA is tightly packed with the help of histone proteins into chromatin. Chromatin architecture can be modified by various post-translational modifications of histone proteins. For almost 60 years now, studies on histone lysine acetylation have unraveled the contribution of this acylation to an open chromatin state with increased DNA accessibility, permissive for gene expression. Additional complexity emerged from the discovery of other types of histone lysine acylations. The acyl group donors are products of cellular metabolism, and distinct histone acylations can link the metabolic state of a cell with chromatin architecture and contribute to cellular adaptation through changes in gene expression. Currently, various technical challenges limit our full understanding of the actual impact of most histone acylations on chromatin dynamics and of their biological relevance. In this review, we summarize the state of the art and provide an overview of approaches to overcome these challenges. We further discuss the concept of subnuclear metabolic niches that could regulate local CoA availability and thus couple cellular metabolisms with the epigenome.
Speaker: Prof. Dr. Thomas Carell
Ludwig-Maximilians-Universität München
Institut für Chemische Epigenetik (ICEM)
Department of Chemistry
Office:
Würmtalstrasse 201
81377 Munich
Germany
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Managing Director: Dr. Oliver Baron
Institute for Chemical Epigenetics Munich (ICEM)
Ludwig-Maximilians-Universität München
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81377 Munich Germany
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Secretary: Birgit Carell
Institute for Chemical Epigenetics Munich (ICEM)
Office:
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81377 Munich
Germany
Mailing address:
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81377 Munich
Germany
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Prof. Dr. Hendrik Zipse (Spokesman)
LMU Munich
Department of Chemistry
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81377 Munich, Germany
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LMU Munich
Department of Chemistry
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81377 Munich Germany
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Dr. Martin Sumser (Coordinator)
LMU Munich
Department of Chemistry
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81377 Munich Germany
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