Display selection of peptide ligands for helical aromatic foldamers

2025-04-03

Lingfei Wang, Joseph M. Rogers, Simon J. Dawson, Line M. Langhorn, Ryan T. Howard, Sunbum Kwon, Céline Douat, Hiroaki Suga, and Ivan Huc

Org. Biomol. Chem., 2025, 23, 4641

https://doi.org/10.1039/D5OB00228A

Helical aromatic oligoamide foldamers with a cluster of five biogenic side chains at their surface were designed and synthesized. Display selection of thioether macrocyclic peptides against these targets generated low micromolar binders that are highly selective for the side-chain arrangement.