Bromodomain AAA+ ATPases get into shape


Magdalena Murawska and Andreas G. Ladurner

Nucleus, 2020, 11:1, 3234

Bromodomain AAA+ ATPases (ATPases associated with diverse cellular activities) are emerging as oncogenic proteins and compelling targets for anticancer therapies. However, structural and biochemical insight into these machines is missing. A recent study by Cho et al. reports the first cryo-EM structure of a bromodomain AAA+ ATPase and provides first insights into the functions of this putative histone chaperone.