SFB 1309
Loading of Amino Acids onto RNA in a Putative RNA-Peptide World
2023-03-07
Johannes N. Singer, Felix M. Müller, Ewa Węgrzyn, Dr. Christina Hölzl, Hans Hurmiz, Chuyi Liu, Dr. Luis Escobar, Prof. Dr. Thomas Carell
The loading of RNAs with amino acids constitutes the first step toward RNA-based peptide synthesis in a putative prebiotic RNA-peptide world. The efficient loading of RNA strands incorporating N-methylcarbamoyl nucleotides with a series of amino acids is reported. The loaded RNA strands also underwent RNA-based amino acid transfer reactions.
