Disordered protein regions partner up the cBAF remodeler for a chromatin dance

2023-11-02

Maren Heimhalt and Andreas G. Ladurner

Molecular Cell, 83, November 2, 2023

https://doi.org/10.1016/j.molcel.2023.10.002

Intrinsically disordered protein regions form condensates and mediate interactions with factors that regulate gene activity. Patil et al.1 decode how such regions within the chromatin remodeler cBAF choreograph selfcondensation and non-self interactions with transcriptional regulators, potentially impacting disease.