SFB 1309
Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists
2022-07-25
Samuele Stazzoni, Daniel F. R. Böhmer, Fabian Hernichel, Dilara Özdemir, Aikaterini Pappa, David Drexler, Stefan Bauernfried, Gregor Witte, Mirko Wagner, Simon Veth, Karl-Peter Hopfner, Veit Hornung, Lars M. König, and Thomas Carell
Angew. Chem. Int. Ed. 2022, 61, e202207175 (1 of 5), 2022
Dideoxy-cyclic-dinucleotide analogs of cGAS/STING second messenger 2′,3′-cGAMP are prepared using a new and concise synthetic combination of phosphoramidite and phosphotriester chemistry. The dideoxy analogs are found to exhibit remarkable in cellulo and in vitro properties, are stable against degradation by poxvirus immune nucleases, and exhibit superior tumor growth control in a mouse model.
