Area B: Modifications on Proteins

Project B06 – Lysine acetylation and succinylation in the core of the nucleosome

Histones form the building blocks of chromatin. Covalent modifications of these histone proteins regulate all DNA dependent processes. Currently very little is known about modifications within the core of the nucleosome. We want to study the role of lysine acetylations in the nucleosomal core and in particular combinations of these acetylations in chromatin dynamics and transcription. Furthermore, we want to unravel the function of a novel acylation, lysine succinylation. Together this will give us new insights in how PTMs can regulate chromatin function.