SFB 1309 Research Areas
Area B: Modifications on Proteins
Project B05 – Molecular insights into altered DNA modifications caused by TET3 deficiency / Beck-Fahrner syndrome
The work program consists of three aims. In Aim A, we will investigate the mechanism of TET3-dependent 5fC formation and DNA demethylation in general. In Aim B, we will investigate the role of TET3 and DNA demethylation in two important cell fate decisions in retinal development: photoreceptor vs. bipolar cell and rod vs. cone photoreceptor.
In Aim C, we will investigate (gene) therapeutic approaches as potential future treatments of TET3 deficiency, a Mendelian neurodevelopmental disorder in humans for which there is currently no treatment.
