Publications

A Phosphotriester-Masked Dideoxy-cGAMP Derivative as a Cell-Permeable STING Agonist

Direct RNA sequencing of the Escherichia coli epitranscriptome uncovers alterations under heat stress

Depletion of m6A-RNA in Escherichia coli reduces the infectious potential of T5 bacteriophage

Isofunctional but Structurally Different Methyltransferases for Dithiolopyrrolone Diversification

Gradual evolution of a homo-L-peptide world on homo-D-configured RNA and DNA

Decrypting the functional design of unmodified translation elongation factor P

Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments

Unveiling the Dynamic Self-Assembly of a Recombinant Dragline-Silk-Mimicking Protein

Enhancing the Features of DNA Mimic Foldamers for Structural Investigations

Characterization of the cystargolide biosynthetic gene cluster and functional analysis of the methyltransferase CysG

Synthesis and Structure Elucidation of Glutamyl-Queuosine

Pitfalls in RNA Modification Quantification Using Nucleoside Mass Spectrometry

The histone chaperone ANP32B regulates chromatin incorporation of the atypical human histone variant macroH2A

The fruit fly acetyltransferase chameau promotes starvation resilience at the expense of longevity

DNA mimic foldamers affect chromatin composition and disturb cell cycle progression

Chemoproteomic target deconvolution reveals Histone Deacetylases as targets of (R)-lipoic acid

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Loading of Amino Acids onto RNA in a Putative RNA-Peptide World

UHMK1 is a novel splicing regulatory kinase

Efficient Method for the Computation of Frozen-Core Nuclear Gradients within the Random Phase Approximation

Altered expression response upon repeated gene repression in single yeast cells

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line

From free-energy profiles to activation free energies

XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead

A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria

Statistically optimal analysis of the extended-system adaptive biasing force (eABF) method

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

A prebiotically plausible scenario of an RNA–peptide world

Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

Exponential averaging versus umbrella sampling for computing the QM/MM free energy barrier of the initial step of the desuccinylation reaction catalyzed by sirtuin 5†

Factors That Determine the Variation of Equilibrium and Kinetic Properties of QM/MM Enzyme Simulations: QM Region, Conformation, and Boundary Condition

¹H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives

Structure and mechanism of the RNA dependent RNase Cas13a from Rhodobacter capsulatus

Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 2 5‑Hydroxymethylcytosine/5-Methylcytosine CpG Dyads

Benchmarking the Accuracy of the Direct Random Phase Approximation and σ‑Functionals for NMR Shieldings

Evolution of a histone variant involved in compartmental regulation of NAD metabolism

A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Intragenomic Decarboxylation of 5-Carboxy-2′-deoxycytidine

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

Analysis of the epitranscriptome with ion-pairing reagent free oligonucleotide mass spectrometry

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin

5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Highly Efficient Resolution-of-Identity Density Functional Theory Calculations on Central and Graphics Processing Units

Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

A Short Approach to N-Aryl-1,2,3,4-tetrahydroisoquinolines from N-(2-Bromobenzyl)anilines via a Reductive Amination/Palladium- Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence

The Enzymatic Decarboxylation Mechanism of 5-Carboxy Uracil: A Comprehensive Quantum Chemical Study

Machine learning a model for RNA structure prediction

Efficient Reduced-Scaling Second-Order Møller−Plesset Perturbation Theory with Cholesky-Decomposed Densities and an Attenuated Coulomb Metric

A set of rhamnosylation-specific antibodies enables detection of novel protein glycosylations in bacteria

Active turnover of genomic methylcytosine in pluripotent cells

Proteome activity landscapes of tumor cell lines determine drug responses

Impact of 5-formylcytosine on the melting kinetics of DNA by ¹H NMR chemical exchange

Rational Design of Covalent Cobaloxime−Covalent Organic Framework Hybrids for Enhanced Photocatalytic Hydrogen Evolution

Folding and Unfolding of the Short Light-Triggered β‑Hairpin Peptide AzoChignolin Occurs within 100 ns

Synthesis and metabolic fate of 4-methylthiouridine in bacterial tRNA

Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes

Predicting ¹⁹F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex

Bromodomain AAA+ ATPases get into shape

Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues

Highly Efficient, Linear-Scaling Seminumerical Exact-Exchange Method for Graphic Processing Units

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

Non‑uniform sampling in quantitative assessment of heterogeneous solid‑state NMR line shapes

TLR8 Is a Sensor of RNase T2 Degradation Products

ProteomicsDB: a multi-omics and multi-organism resource for life science research

A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine

Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary ¹⁵N and ¹H Relaxation Dispersion Techniques

The interactome of a family of potential methyltransferases in HeLa cells

Label‐Free Quantification of 5‐Azacytidines Directly in the Genome

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis