Aryl Radicals Generated from Aryl Pinacol Boronates Modify Peptides and Proteins

A Phosphotriester-Masked Dideoxy-cGAMP Derivative as a Cell-Permeable STING Agonist

Aryl Radicals Generated from Aryl Pinacol Boronates Modify Peptides and Proteins

Interrogating the potential of helical aromatic foldamers for protein recognition

Improved deconvolution of natural products’ protein targets using diagnostic ions from chemical proteomics linkers

Deciphering the SAM- and metal-dependent mechanism of O-methyltransferases in cystargolide and belactosin biosynthesis: A structure–activity relationship study

Emerging toolkits for decoding the co-occurrence of modified histones and chromatin proteins

The type of DNA damage response after decitabine treatment depends on the level of DNMT activity

Efficient Tandem Copper-Catalyzed Click Synthesis of Multisugar-Modified Oligonucleotides

Potent hydroxamate-derived compounds arrest endodyogeny of Toxoplasma gondii tachyzoites

Polyketide Trimming Shapes Dihydroxynaphthalene-Melanin and Anthraquinone Pigments

RNA-Templated Peptide Bond Formation Promotes L-Homochiralty

Exploring Chemical Space Using Ab Initio Hyperreactor Dynamics

Cu-Catalyzed Azide−Alkyne−Thiol Reaction Forms Ubiquitous Background in Chemical Proteomic Studies

3′‑tRF‑Cys^GCA overexpression in HEK‑293 cells alters the global expression profile and modulates cellular processes and pathways

Experience with German Research Consortia in the Field of Chemical Biology of Native Nucleic Acid Modifications

Disordered protein regions partner up the cBAF remodeler for a chromatin dance

The role of RNA in the maintenance of chromatin domains as revealed by antibody mediated proximity labelling coupled to mass spectrometry

Display Selection of a Hybrid Foldamer–Peptide Macrocycle

Pharmacological perturbation of the phase-separating protein SMNDC1

Conformation and structural dynamics of the Xist lncRNA A‐repeats

Depletion of pyruvate kinase (PK) activity causes glycolytic intermediate imbalances and reveals a PK-TXNIP regulatory axis

Decrypting drug actions and protein modifications by dose- and time-resolved proteomics

Loading of Amino Acids onto RNA in a Putative RNA-Peptide World

UHMK1 is a novel splicing regulatory kinase

Quantitative RNA imaging in single live cells reveals age-dependent asymmetric inheritance

Fully Automated Generation of Prebiotically Relevant Reaction Networks from Optimized Nanoreactor Simulations

Chemical Proteomics Reveals Protein Tyrosination Extends Beyond the Alpha-Tubulins in Human Cells

Accelerating Hybrid Density Functional Theory Molecular Dynamics Simulations by Seminumerical Integration, Resolution-of-the-Identity Approximation, and Graphics Processing Units

Isoxazole Nucleosides as Building Blocks for a Plausible Proto-RNA

Epipolythiodioxopiperazine-Based Natural Products: Building Blocks, Biosynthesis and Biological Activities

XPC–PARP complexes engage the chromatin remodeler ALC1 to catalyze global genome DNA damage repair

Pathogenic bacteria remodel central metabolic enzyme to build a cyclopropanol warhead

A Specialized Polythioamide-Binding Protein Confers Antibiotic Self-Resistance in Anaerobic Bacteria

Statistically optimal analysis of the extended-system adaptive biasing force (eABF) method

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

A prebiotically plausible scenario of an RNA–peptide world

Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

Exponential averaging versus umbrella sampling for computing the QM/MM free energy barrier of the initial step of the desuccinylation reaction catalyzed by sirtuin 5†

Epigenetic Anti-Cancer Treatment With a Stabilized Carbocyclic Decitabine Analogue

Structural effects of m6 A modification of the Xist A-repeat AUCG tetraloop and its recognition by YTHDC1

Clickable report tags for identification of modified peptides by mass spectrometry

The pH-Dependence of the Hydration of 5-Formylcytosine - an Experimental and Theoretical Study

Atomic-resolution chemical characterization of (2x)72-kDa tryptophan synthase via four- and five-dimensional ¹H-detected solid-state NMR

Linking post-translational modifications and protein turnover by site-resolved protein turnover profiling

Benchmarking the Accuracy of the Direct Random Phase Approximation and σ‑Functionals for NMR Shieldings

Evolution of a histone variant involved in compartmental regulation of NAD metabolism

A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Intragenomic Decarboxylation of 5-Carboxy-2′-deoxycytidine

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

Analysis of the epitranscriptome with ion-pairing reagent free oligonucleotide mass spectrometry

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin

5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Highly Efficient Resolution-of-Identity Density Functional Theory Calculations on Central and Graphics Processing Units

Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

A Short Approach to N-Aryl-1,2,3,4-tetrahydroisoquinolines from N-(2-Bromobenzyl)anilines via a Reductive Amination/Palladium- Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence

The Enzymatic Decarboxylation Mechanism of 5-Carboxy Uracil: A Comprehensive Quantum Chemical Study

Machine learning a model for RNA structure prediction

Efficient Reduced-Scaling Second-Order Møller−Plesset Perturbation Theory with Cholesky-Decomposed Densities and an Attenuated Coulomb Metric

A set of rhamnosylation-specific antibodies enables detection of novel protein glycosylations in bacteria

Active turnover of genomic methylcytosine in pluripotent cells

Proteome activity landscapes of tumor cell lines determine drug responses

Impact of 5-formylcytosine on the melting kinetics of DNA by ¹H NMR chemical exchange

Rational Design of Covalent Cobaloxime−Covalent Organic Framework Hybrids for Enhanced Photocatalytic Hydrogen Evolution

Folding and Unfolding of the Short Light-Triggered β‑Hairpin Peptide AzoChignolin Occurs within 100 ns

Synthesis and metabolic fate of 4-methylthiouridine in bacterial tRNA

Current approaches for integrating solution NMR spectroscopy and small-angle scattering to study the structure and dynamics of biomolecular complexes

Predicting ¹⁹F NMR Chemical Shifts: A Combined Computational and Experimental Study of a Trypanosomal Oxidoreductase–Inhibitor Complex

Bromodomain AAA+ ATPases get into shape

Synthesis of Galactosyl-Queuosine and Distribution of Hypermodified Q-Nucleosides in Mouse Tissues

Highly Efficient, Linear-Scaling Seminumerical Exact-Exchange Method for Graphic Processing Units

Localized Inhibition of Protein Phosphatase 1 by NUAK1 Promotes Spliceosome Activity and Reveals a MYC-Sensitive Feedback Control of Transcription

Robust, reproducible and quantitative analysis of thousands of proteomes by micro-flow LC–MS/MS

Non‑uniform sampling in quantitative assessment of heterogeneous solid‑state NMR line shapes

TLR8 Is a Sensor of RNase T2 Degradation Products

ProteomicsDB: a multi-omics and multi-organism resource for life science research

A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine

Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary ¹⁵N and ¹H Relaxation Dispersion Techniques

The interactome of a family of potential methyltransferases in HeLa cells

Label‐Free Quantification of 5‐Azacytidines Directly in the Genome

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis