Publications

Efficient Method for the Computation of Frozen-Core Nuclear Gradients within the Random Phase Approximation

Altered expression response upon repeated gene repression in single yeast cells

Aza-SAHA Derivatives Are Selective Histone Deacetylase 10 Chemical Probes That Inhibit Polyamine Deacetylation and Phenocopy HDAC10 Knockout

Comprehensive comparison between azacytidine and decitabine treatment in an acute myeloid leukemia cell line

From free-energy profiles to activation free energies

Tensor-Hypercontracted MP2 First Derivatives: Runtime and Memory Efficient Computation of Hyperfine Coupling Constants

Novel Poxin Stable cGAMP-Derivatives Are Remarkable STING Agonists

Statistically optimal analysis of the extended-system adaptive biasing force (eABF) method

Development of hetero-triaryls as a new chemotype for subtype-selective and potent Sirt5 inhibition

A prebiotically plausible scenario of an RNA–peptide world

Structural insights into cooperative DNA recognition by the CCAAT-binding complex and its bZIP transcription factor HapX

Exponential averaging versus umbrella sampling for computing the QM/MM free energy barrier of the initial step of the desuccinylation reaction catalyzed by sirtuin 5†

Factors That Determine the Variation of Equilibrium and Kinetic Properties of QM/MM Enzyme Simulations: QM Region, Conformation, and Boundary Condition

¹H NMR chemical exchange techniques reveal local and global effects of oxidized cytosine derivatives

Structure and mechanism of the RNA dependent RNase Cas13a from Rhodobacter capsulatus

Evolved DNA Duplex Readers for Strand-Asymmetrically Modified 2 5‑Hydroxymethylcytosine/5-Methylcytosine CpG Dyads

Benchmarking the Accuracy of the Direct Random Phase Approximation and σ‑Functionals for NMR Shieldings

Evolution of a histone variant involved in compartmental regulation of NAD metabolism

A modular toolbox to generate complex polymeric ubiquitin architectures using orthogonal sortase enzymes

The histone chaperone FACT facilitates heterochromatin spreading by regulating histone turnover and H3K9 methylation states

Intragenomic Decarboxylation of 5-Carboxy-2′-deoxycytidine

Chemical synthesis of linear ADP-ribose oligomers up to pentamer and their binding to the oncogenic helicase ALC1

Analysis of the epitranscriptome with ion-pairing reagent free oligonucleotide mass spectrometry

Redirected nuclear glutamate dehydrogenase supplies Tet3 with α-ketoglutarate in neurons

Histone acylations and chromatin dynamics: concepts, challenges, and links to metabolism

Structural and Mechanistic Insights into C−S Bond Formation in Gliotoxin

5-Hydroxymethyl-, 5-Formyl- and 5-Carboxydeoxycytidines as Oxidative Lesions and Epigenetic Marks

Metabolic Analysis of Vitreous/Lens and Retina in Wild Type and Retinal Degeneration Mice

Highly Efficient Resolution-of-Identity Density Functional Theory Calculations on Central and Graphics Processing Units

Succinylation of H3K122 destabilizes nucleosomes and enhances transcription

A Short Approach to N-Aryl-1,2,3,4-tetrahydroisoquinolines from N-(2-Bromobenzyl)anilines via a Reductive Amination/Palladium- Catalyzed Ethoxyvinylation/Reductive N-Alkylation Sequence

The Enzymatic Decarboxylation Mechanism of 5-Carboxy Uracil: A Comprehensive Quantum Chemical Study

Machine learning a model for RNA structure prediction

Efficient Reduced-Scaling Second-Order Møller−Plesset Perturbation Theory with Cholesky-Decomposed Densities and an Attenuated Coulomb Metric

METTL6 is a tRNA m³C methyltransferase that regulates pluripotency and tumor cell growth

Welcome @ SFB1309!

Identification of the subtype-selective Sirt5 inhibitor balsalazide through systematic SAR analysis and rationalization via theoretical investigations

Restraining and unleashing chromatin remodelers – structural information guides chromatin plasticity

Protein Motional Details Revealed by Complementary Structural Biology Techniques

Important components for accurate hyperfine coupling constants: electron correlation, dynamic contributions, and solvation effects

Structural basis of HapEP88L-linked antifungal triazole resistance in Aspergillus fumigatus

Single-Cell Tracing Dissects Regulation of Maintenance and Inheritance of Transcriptional Reinduction Memory

You are what you eat – How nutrition and metabolism shape the genome through epigenetics

The rRNA m⁶A methyltransferase METTL5 is involved in pluripotency and developmental programs

 

Structures in Tetrahydrofolate Methylation in Desulfitobacterial Glycine Betaine Metabolism at Atomic Resolution

Synthesis and Incorporation of k²U into RNA

The Chaperone FACT and Histone H2B Ubiquitination Maintain S. pombe Genome Architecture through Genic and Subtelomeric Functions

Analysis of an Active Deformylation Mechanism of 5‐Formyl‐deoxycytidine (fdC) in Stem Cells

Non‑uniform sampling in quantitative assessment of heterogeneous solid‑state NMR line shapes

TLR8 Is a Sensor of RNase T2 Degradation Products

ProteomicsDB: a multi-omics and multi-organism resource for life science research

A Click‐Chemistry‐Based Enrichable Crosslinker for Structural and Protein Interaction Analysis by Mass Spectrometry

Proto‐Urea‐RNA (Wöhler RNA) Containing Unusually Stable Urea Nucleosides

Challenges and perspectives for structural biology of lncRNAs—the example of the Xist lncRNA A-repeats

Influencing Epigenetic Information with a Hydrolytically Stable Carbocyclic 5‐Aza‐2′‐deoxycytidine

Mechanistic Insights into Microsecond Time-Scale Motion of Solid Proteins Using Complementary ¹⁵N and ¹H Relaxation Dispersion Techniques

The interactome of a family of potential methyltransferases in HeLa cells

Label‐Free Quantification of 5‐Azacytidines Directly in the Genome

Production and Application of Stable Isotope-Labeled Internal Standards for RNA Modification Analysis