SFB 1309 Research Areas
Area B: Modifications on Proteins
Project B08 – Mass Spectrometry-based Chemical Proteomics analysis of Protein Glutamylation
Protein post-translational modifications are chemical modifications on proteins that modulate protein catalytic activity, subcellular localization and interaction with other proteins in the cell. In this project, we focus on protein glutamylation, which regulates in cells function of microtubules and its dysregulation has been associated with cancer, neurodegeneration and retinitis pigmentosa. We will use small compound probe to track protein glutamylation in retinal organoids with cell type resolution and develop protein glutamylation inhibitors to delineate basic biological process regulated by this protein modification.
