Area C: Mechanisms and Tools

Project C03 – Acid/Base- and Redox-Properties of modified DNA Bases

Using a combination of experimental measurements and theoretical calculations several key chemical properties of modified DNA bases will be determined. This will include their acid/base profiles, their one-electron redox potentials, and bond energies for the most reactive C-H, O-H and N-H bonds. These fundamental properties will provide a basis for the rationalization of reactivity differences between canonical and modified nucleobases.