Area A: Modifications on Nucleic Acids

Project A01 – Discovery of novel RNA modifications and targets of RNA writer enzymes

We will continue our efforts for the discovery of novel modified nucleosides as we believe that the function of RNA modification can only be understood once the complete network of modifications in an organism is known. With isotope labeling in cell culture we will establish a systematic approach to identify RNA writers and erasers and generate internal standards for modification profile analysis. We plan to study the effect of unnatural nucleosides and nucleic acid metabolism inhibitors on the adaptation of modified nucleosides.