Area C: Mechanisms and Tools

Project C06 – Synthesis and characterization of low-molecular modulators of epigenetic target enzymes

In this project novel inhibitors of histone modifying enzymes, in special type III histone deacetylases (sirtuins), will be developed. Based on our own previous work (for project A) and recently published lead structures (for project B), new, unprecedented chemotypes of inhibitors will be designed. These inhibitors will be valuable chemical tools for cooperating groups in the SFB. Optimization of the inhibitors will be fostered by contributions from other groups in the consortium.