Area B: Modifications on Proteins

Project B02 – Dynamics of epigenetic protein modifications and RNA interactions

In this project, we ask two main questions: first, do post-synthetic modifications influence the interaction of proteins with mRNAs or miRNAs to modulate their function? Second, what are the post-translational modifications that characterize differentiating stem cells and how can we exploit this chemically to kill cancer stem cells. Both questions will be approached by a combination of mass spectrometry based quantitative proteomics and bioinformatics.