Area A: Modifications on Nucleic Acids

Project A02 – Effects of posttranscriptional chemical modifications on RNA structure, dynamics and protein recognition

The molecular, structural and functional consequences of chemical RNA modifications involving adenosine-to-inosine (A-to-I) editing and m6A RNA methylation are studied. Using biochemical methods, solution-state NMR and complementary techniques the effects of A-to-I-editing and base m6A methylation on the conformation, internal dynamics and molecular interactions will be studied. The results will provide unprecedented insight and high-resolution structural information for the effects of chemical modifications of eukaryotic RNAs with important functions in posttranscriptional gene regulation.