Pioneers conquer core histones at the chromatin frontier


Magdalena Murawska, Andreas G. Ladurner & Carla E. Margulies

Nat.Struct.Mol Biol,1050–1053, 2023

Pioneer transcription factors access gene regulatory sites embedded within chromatin. They drive gene expression programs vital for cell fate decisions and cellular reprogramming, but how they engage nucleosomal sites at the molecular level is unclear. New results show that they engage histones and collaborate to overcome the nucleosome barrier.